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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

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Investigating homology between proteins using energetic profiles.

James O Wrabl1, Vincent J Hilser

  • 1Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America.

Plos Computational Biology
|April 3, 2010
PubMed
Summary

Local protein stability is generally conserved throughout evolution among homologous proteins. However, the thermodynamic mechanisms (enthalpy and entropy) driving stability show less conservation, suggesting fold evolution can occur via altered mechanisms.

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