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Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Related Experiment Video

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A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
04:05

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

Published on: May 31, 2024

NSAID-induced colopathy. A case series.

Abdur R Aftab1, Fergal Donnellan, Faisal Zeb

  • 1Department of Gastroenterology, St. Luke's Hospital, Kilkenny, Ireland. aftabar@hotmail.com

Journal of Gastrointestinal and Liver Diseases : JGLD
|April 3, 2010
PubMed
Summary

Non-steroidal anti-inflammatory drug (NSAID) colopathy, or large intestine damage, is increasingly recognized. This condition can cause severe symptoms like bloody diarrhea and anemia, necessitating greater awareness and prompt diagnosis.

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Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

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Last Updated: Jun 14, 2026

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
04:05

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

Published on: May 31, 2024

Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Pharmacology

Background:

  • Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs) are well-documented for the upper gastrointestinal tract and small intestine.
  • NSAID colopathy, affecting the large intestine, is less understood but clinically significant.

Observation:

  • Four cases of NSAID colopathy are presented, detailing characteristic endoscopic findings.
  • One case illustrates the natural history, progressing from acute inflammation and ulceration to chronic fibrous strictures.
  • Clinical presentations included bloody diarrhea and symptomatic anemia.

Findings:

  • NSAID-induced colonic damage presents with diverse endoscopic features.
  • The condition can manifest acutely with inflammation and ulceration, or chronically with stricture formation.
  • Patient outcomes highlight the severity, with significant gastrointestinal bleeding and anemia.

Implications:

  • Increasing use of enteric-coated and sustained-release NSAIDs may lead to more frequent cases of NSAID colopathy.
  • Enhanced awareness of clinical and endoscopic findings is crucial for timely diagnosis and effective management.
  • Prompt diagnosis and treatment are essential to mitigate severe complications associated with NSAID colopathy.