Related Experiment Video
Updated: Jun 8, 2026

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
Published on: February 15, 2018
Does breastfeeding protect against sudden infant death syndrome?
Insights
Breastfeeding may protect infants from Sudden Infant Death Syndrome (SIDS), the leading cause of infant mortality. Further research is needed to define breastfeeding types to confirm this protective effect against SIDS.
Area of Science:
- Pediatrics
- Public Health
- Neonatology
Background:
- Sudden Infant Death Syndrome (SIDS) is the primary cause of death for infants aged 1-6 months in developed nations.
- SIDS affects approximately 2 in 1000 live births in the U.S., with non-specific infant characteristics, making diagnosis challenging.
- Diagnosis of SIDS requires the exclusion of all other known causes of death after thorough examination.
Purpose of the Study:
- To review prominent hypotheses regarding the causes of SIDS.
- To explore scientific evidence suggesting a protective effect of breastfeeding against SIDS.
- To highlight the need for standardized definitions of breastfeeding in SIDS research.
Main Methods:
- Literature review of proposed SIDS hypotheses.
- Analysis of scientific findings on the association between breastfeeding and SIDS incidence.
- Identification of research gaps concerning breastfeeding definitions.
Main Results:
- Numerous SIDS hypotheses exist, including infant-related issues (e.g., sleep/breathing control defects, infections) and maternal factors (e.g., socioeconomic status, smoking).
- Many proposed SIDS risk factors are associated with a lack of breastfeeding.
- Breastfed infants exhibit a substantially lower incidence rate of SIDS.
Conclusions:
- Breastfeeding is speculated to offer protection against SIDS.
- Lack of uniform definitions for breastfeeding (exclusive vs. partial) hinders precise research.
- Standardized definitions are crucial for further elucidating the protective mechanisms of breastfeeding against SIDS.
Abstract:
Sudden Infant Death Syndrome (SIDS), the leading cause of infant death from one to six months in the developed world, strikes approximately two infants per 1000 live births in the U.S. The characteristics of the infants who die suddenly and unexpectedly are non-specific; none are universal except for the age distribution. Therefore, an infant is recognized to have died from SIDS only after thorough examination fails to demonstrate any other cause for the death. It is the purpose of this paper to review the most populat hypotheses of the causes of SIDS and try to explain through published scientific findings how breastfed infants appear to be protected from this condition. Many hypotheses have been proposed to explain SIDS. Some deficiencies/problems are related to the infant, such as a defect in sleep and/or breathing control, severe infant botulism, infections, reactions to immunizations, hypersensitivity to cow's milk, "maternal deprivation syndrome." Other causes are attributed to maternal circumstances, such as lower socioeconomic status, prenatal health, smoking, and the winter season. Additional suggestions of potential causes of SIDS include baby's thiamine deficiency, and hormonal and/or biochemical imbalance. The occurrence of most of these circumstances can be associated with a lack of breastfeeding. Because SIDS occurs much less frequently in breastfed infants, it is speculated that breastfeeding protects infants against SIDS. However, scientific literature lacks uniformity in the definitions of breastfeeding (whether partial and exclusive). This specification is necessary to select control infants to elucidate the well documented substantial lower rate of incidence of SIDS in breastfed babies.
More Related Videos
08:12Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets
Published on: September 6, 2019
05:04A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect
Published on: September 22, 2023
Related Concept Videos
Parental Care
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Attachment
Development of Human Microbiota
Development of the Oral Microbiota
Respiratory Syncytial Virus Disease