Monte carlo simulation of heterotypic cell aggregation in nonlinear shear flow
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Published on: February 6, 2014
Jiakou Wang1, Margaret J Slattery, Meghan Henty Hoskins
1Department of Mathematics, Penn State University, University Park, PA 16802. jiakou@math.psu.edu.
Abstract:
In this paper, we develop a population balance model for cell aggregation and adhesion process in a nonuniform shear flow. Some Monte Carlo simulation results based on the model are presented for the heterotypic cell-cell collision and adhesion to a substrate under dynamic shear forces. In particular, we focus on leukocyte (PMN)-melanoma cell emboli formation and subsequent tethering to the vascular endothelium (EC) as a result of cell-cell aggregation. The simulation results are compared with the results of experimental measurement. Discussions are made on how we could further improve the accuracy of the population balance type modelling.
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