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Related Concept Videos

Microtubules in Signaling01:22

Microtubules in Signaling

The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...

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Related Experiment Video

Updated: Jun 14, 2026

Simple Detection of Primary Cilia by Immunofluorescence
08:07

Simple Detection of Primary Cilia by Immunofluorescence

Published on: May 15, 2020

Primary cilia and the cell cycle.

Olga V Plotnikova1, Elena N Pugacheva, Erica A Golemis

  • 1Program in Molecular and Translational Medicine, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

Methods in Cell Biology
|April 6, 2010
PubMed
Summary
This summary is machine-generated.

Cilia, crucial cell sensors, dynamically grow and shrink with the cell cycle. Understanding this cell cycle control of cilia is key to treating diseases linked to ciliary defects.

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Last Updated: Jun 14, 2026

Simple Detection of Primary Cilia by Immunofluorescence
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Published on: May 15, 2020

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12:02

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Using Primary Neurosphere Cultures to Study Primary Cilia
08:14

Using Primary Neurosphere Cultures to Study Primary Cilia

Published on: April 14, 2017

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Background:

  • Cilia are microtubule-based cell surface structures acting as sensors for mechanical and chemical cues.
  • Cilia play vital roles in metazoan development and adult tissue homeostasis, housing key signaling receptors.
  • Dysfunctional cilia are implicated in developmental disorders, cystic diseases, and cancers.

Purpose of the Study:

  • To review the current understanding of cell cycle control over ciliary dynamics.
  • To highlight the importance of ciliary assembly and disassembly in cellular signaling.
  • To present methods for investigating cell cycle-dependent ciliary regulation.

Main Methods:

  • Literature review of cell cycle control mechanisms affecting cilia.
  • Discussion of signaling pathways involving cilia (Hedgehog, PDGF, Wnt).
  • Overview of experimental approaches for studying ciliary dynamics.

Main Results:

  • Cilia are present in G0/G1 and often S/G2 phases but are resorbed before mitosis.
  • Cell cycle machinery intrinsically regulates periodic ciliary resorption and reassembly.
  • This dynamic regulation impacts cellular response to external signals.

Conclusions:

  • Cell cycle control of ciliary dynamics is a critical area of research.
  • Understanding these mechanisms offers potential insights into disease pathogenesis.
  • Further investigation is needed to fully elucidate regulatory factors for therapeutic development.