Related Experiment Video
Updated: Jun 14, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
[Secondary hyperparathyroidism in advanced prostate cancer]
Susana Quirosa Flores1, Mariela Varsavsky, Francisco Valle Díaz De La Guardia
1Servicio de Reumatología, Hospital Clínico San Cecilio, Granada, España.
Summary
Elevated parathyroid hormone (PTH) levels are observed in advanced prostate cancer patients, particularly those with bone metastases. This finding may help predict disease progression in prostate cancer patients.
Area of Science:
- Endocrinology
- Oncology
- Bone Metabolism
Context:
- Advanced prostate cancer is associated with complex metabolic changes.
- Elevated parathyroid hormone (PTH) is linked to increased bone resorption.
- The role of PTH in prostate cancer pathophysiology requires further elucidation.
Purpose:
- To investigate parathyroid hormone (PTH) levels in patients with advanced prostate cancer.
- To determine the correlation between PTH concentrations and the presence of bone metastases.
- To explore the relationship between PTH, vitamin D, and prostate-specific antigen (PSA) levels.
Summary:
- A retrospective study analyzed 60 advanced prostate cancer patients, measuring PTH, calcium, phosphorus, 25(OH) vitamin D, and PSA.
- Patients with bone metastases exhibited significantly higher PTH levels and lower vitamin D levels compared to those without metastases.
- No significant differences were found in calcium, phosphorus, or PSA levels between the groups.
Impact:
- Increased PTH concentrations may serve as a predictive biomarker for disease progression in advanced prostate cancer.
- Findings suggest a potential link between PTH dysregulation and skeletal complications in prostate cancer.
- Further research can explore therapeutic strategies targeting PTH pathways in prostate cancer management.
Related Concept Videos
00:59The Parathyroid Glands
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
01:27Hyperthyroidism II: Pathophysiology
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
01:25Hyperthyroidism I: Introduction
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:17Hormones and Bone Tissue
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...