Related Experiment Video
Updated: Jun 14, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy
Elena Tarabra1, Paola Pazienza, Elisabetta Borghesio
1Center for Predictive Medicine, Presidio Sanitario Gradenigo, C.so Regina Margherita 8, 10153, Turin, Italy.
Background:
The activity of epithelial lactase (LCT) associates with a polymorphism 13910 bp upstream the LCT-encoding gene (LCT-13910C>T). The relationship between LCT-13910C>T polymorphism and risk for colorectal cancer is unclear.
Aims:
We examined the relationship between the LCT-13910C>T polymorphism causing lactose intolerance and risk for colorectal cancer/polyps onset in the Italian population.
Patients And Methods:
793 subjects (306 with colorectal cancer, 176 with polyps and 311 controls) were genotyped for the LCT-13910C>T variant by TaqMan real time-PCR.
Results:
Lactose malabsorption linked to the CC genotype did not associate with an increased risk for either colorectal cancer (OR=1.041; 95% CI=0.751-1.442; p=0.868) or polyps (OR=0.927; 95% CI=0.630-1.363; p=0.769). There was no association with colorectal cancer/polyps site. 60% of the subjects overall bore the CC genotype.
Conclusion:
In the Italian population the LCT-13910C>T polymorphism is not associated to the risk for colorectal cancer or polyps.
Related Concept Videos
Non-LTR Retrotransposons
Drugs for Treatment of Constipation-Predominant IBS
lncRNA - Long Non-coding RNAs
Microbiota of the Large Intestine
Inflammatory Bowel Disease III: Crohn's Disease
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

