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Incremental effect for antisocial personality disorder genetic risk combining 5-HTTLPR and 5-HTTVNTR polymorphisms
Luis F Garcia1, Anton Aluja, Joan Fibla
1Department of Biological and Health Psychology, Autonomous University of Madrid, Madrid, Spain. luis.garcia@uam.es
Psychiatry Research
|April 6, 2010
Summary
The serotonin transporter gene (SLC6A4) polymorphisms, specifically 5-HTTLPR and 5-HTTVNTR, are linked to Antisocial Personality Disorder (APD). Certain SLC6A4 genotypes increase the risk for APD in male inmates.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- The serotonin transporter gene (SLC6A4 or 5-HTT) regulates central serotonergic activity.
- Previous association studies have explored the link between SLC6A4 polymorphisms and Antisocial Personality Disorder (APD).
Purpose of the Study:
- To investigate the role of 5-HTTLPR and 5-HTTVNTR polymorphisms of the SLC6A4 gene in APD.
- To examine the association between specific SLC6A4 genotypes and APD risk in a sample of male inmates.
Main Methods:
- Analyzed a sample of 147 male inmates.
- Assessed APD using Aluja's Antisocial Personality Disorder Scale.
- Examined 5-HTTLPR and 5-HTTVNTR polymorphisms of the SLC6A4 gene.
Main Results:
- Inmates with combined 5-HTTLPR S/S+S/L and 5-HTTVNTR 12/12 genotypes had a 3.48-fold higher risk of APD.
- Genotype and haplotype distributions differed significantly when comparing extreme APD groups (odds ratios up to 6.50).
Conclusions:
- The 5-HTTVNTR polymorphism, alongside the 5-HTTLPR, is a potential candidate for APD association studies.
- Under-representation of severe APD cases in previous studies may explain failed replication of SLC6A4-APD associations.
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