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Related Concept Videos

The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...

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Related Experiment Video

Updated: Jun 14, 2026

A High-content Assay for Monitoring AMPA Receptor Trafficking
10:34

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

Dendritic ion channel trafficking and plasticity.

Mala M Shah1, Rebecca S Hammond, Dax A Hoffman

  • 1Department of Pharmacology, The School of Pharmacy, University of London, London, WC1N 1AX, UK. mala.shah@pharmacy.ac.uk

Trends in Neurosciences
|April 6, 2010
PubMed
Summary

Dendritic ion channels regulate neuron excitability and synaptic integration. Their modulation and trafficking are key to understanding neuronal plasticity and information processing.

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3D Modeling of Dendritic Spines with Synaptic Plasticity
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Related Experiment Videos

Last Updated: Jun 14, 2026

A High-content Assay for Monitoring AMPA Receptor Trafficking
10:34

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

Brain Slice Biotinylation: An Ex Vivo Approach to Measure Region-specific Plasma Membrane Protein Trafficking in Adult Neurons
06:18

Brain Slice Biotinylation: An Ex Vivo Approach to Measure Region-specific Plasma Membrane Protein Trafficking in Adult Neurons

Published on: April 3, 2014

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Molecular Biology

Background:

  • Dendritic ion channels are critical for neuronal excitability and synaptic signal processing.
  • Alterations in dendritic channel function are linked to various forms of synaptic plasticity.
  • Emerging evidence implicates dendritic ion channel modulation and trafficking in plasticity-related neuronal changes.

Purpose of the Study:

  • To review current knowledge on dendritic ion channel modulation and trafficking.
  • To explore the relationship between these processes and cellular/synaptic plasticity.
  • To discuss the implications for overall neuronal function and information processing.

Main Methods:

  • Literature review of existing research on dendritic ion channels.
  • Synthesis of findings on ion channel modulation and trafficking.
  • Analysis of the connection to synaptic plasticity mechanisms.

Main Results:

  • Dendritic ion channel modulation and trafficking significantly influence neuronal excitability.
  • These processes are integral to the mechanisms underlying synaptic plasticity.
  • Understanding these dynamics is crucial for comprehending neuronal information processing.

Conclusions:

  • Dendritic ion channel regulation is fundamental to neuronal plasticity.
  • Further investigation into dendritic ion channel expression and properties is essential.
  • This knowledge is vital for a comprehensive understanding of neuronal information processing.