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Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
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Published on: May 30, 2011

Technical aspects of MR perfusion.

Steven Sourbron1

  • 1Division of Medical Physics, University of Leeds, Worsley Building, Clarendon Way, LS2 9JT Leeds, UK. s.sourbron@leeds.ac.uk

European Journal of Radiology
|April 6, 2010
PubMed
Summary

Dynamic contrast enhancement MRI (DCE-MRI) is a key technique for measuring tissue perfusion and capillary permeability. This review covers the essential technical aspects of DCE-MRI data acquisition and analysis for accurate hemodynamic parameter assessment.

Area of Science:

  • Radiology and Imaging Science
  • Biomedical Engineering
  • Medical Physics

Background:

  • Magnetic Resonance Imaging (MRI) offers multiple methods for perfusion measurement, including Arterial Spin Labelling (ASL), Dynamic Susceptibility Contrast (DSC-MRI), and T(1)-weighted Dynamic Contrast Enhancement (DCE-MRI).
  • DCE-MRI is the most prevalent body imaging technique, providing insights into capillary permeability alongside perfusion.
  • A comprehensive understanding of DCE-MRI's technical facets is crucial for its effective application.

Purpose of the Study:

  • To provide a concise yet thorough overview of the technical challenges in DCE-MRI data acquisition and analysis.
  • To present a generic, technically focused review applicable to all DCE-MRI measurements.
  • To define fundamental quantities and physical mechanisms relating hemodynamic parameters to DCE-MRI signals.

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Main Methods:

  • Review of technical issues in DCE-MRI data acquisition, focusing on optimal protocol design.
  • Summary of data analysis steps required for determining hemodynamic parameters from acquired DCE-MRI data.
  • Discussion of theoretical underpinnings, including basic quantity definitions and physical mechanisms.

Main Results:

  • Detailed examination of factors influencing DCE-MRI data acquisition quality.
  • Structured approach to analyzing DCE-MRI data for extracting hemodynamic information.
  • Theoretical framework connecting MRI signal changes to physiological parameters like perfusion and permeability.

Conclusions:

  • DCE-MRI is a versatile technique for assessing tissue perfusion and capillary permeability.
  • Mastery of DCE-MRI data acquisition and analysis protocols is essential for reliable hemodynamic measurements.
  • This review serves as a foundational guide to the technical aspects of DCE-MRI.