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Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
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Interaction study between levofloxacin and omeprazole using urinary pharmacokinetic data.

Chowdhury Farhana Faruquee1, Ashik Ullah, Mohammad Abul Kalam Azad

  • 1Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka-1000, Bangladesh.

Pakistan Journal of Pharmaceutical Sciences
|April 6, 2010
PubMed
Summary

This study found no significant drug interaction between levofloxacin and omeprazole. Urinary excretion data showed that co-administration of these antibiotics and proton pump inhibitors is safe for optimal therapeutic activity.

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Area of Science:

  • Pharmacology
  • Drug Interactions
  • Clinical Pharmacy

Background:

  • Drug interactions can alter pharmacokinetic profiles, affecting efficacy and safety.
  • Levofloxacin (antibiotic) and omeprazole (proton pump inhibitor) are commonly prescribed medications.
  • Understanding potential interactions is crucial for safe and effective patient care.

Purpose of the Study:

  • To investigate potential drug interactions between levofloxacin and omeprazole.
  • To evaluate the impact of co-administration on the pharmacokinetic profiles of both drugs using urinary excretion data.

Main Methods:

  • Administered levofloxacin and omeprazole separately and in combination to participants under fasting conditions.
  • Collected urine samples at various time intervals (0-48 hours) post-dose.
  • Analyzed samples using High-Performance Liquid Chromatography (HPLC) with UV detection to determine pharmacokinetic parameters.

Main Results:

  • No significant changes were observed in the maximum rate of excretion (Rmax) for either levofloxacin or omeprazole when co-administered.
  • The fraction of drug excreted (fe/f) remained unaffected for both levofloxacin and omeprazole.
  • Area Under the Rate of Excretion Curve (AURC) showed no significant alteration for either drug.

Conclusions:

  • Levofloxacin and omeprazole do not exhibit significant drug interactions when administered together.
  • Co-administration of levofloxacin and omeprazole is considered safe.
  • These drugs can be prescribed concurrently to achieve optimal therapeutic outcomes.