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Updated: Jun 14, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
Minireview: Estrogen receptor-beta: mechanistic insights from recent studies
Bonnie J Deroo1, Adrian V Buensuceso
1The University of Western Ontario, Room A4-144, Children's Health Research Institute, 800 Commissioners Road East, London, Ontario, Canada N6C 2V5. bderoo2@uwo.ca
Abstract:
The discovery of estrogen receptor-beta (ERbeta) in 1996 stimulated great interest in the physiological roles and molecular mechanisms of ERbeta action. We now know that ERbeta plays a major role in mediating estrogen action in several tissues and organ systems, including the ovary, cardiovascular system, brain, and the immune system, and that ERbeta and ERalpha generally play distinct physiological roles in the body. Although significant progress has been made toward understanding the molecular mechanisms of ERbeta action, particularly in vitro, there remains a large gap in our understanding of the mechanisms by which ERbeta elicits its biological functions in a true physiological context.
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