Related Experiment Video
Updated: Jun 14, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
Published on: July 9, 2014
[The impact of multiple vaccinations on vaccine schedule adherence and parental attitudes in Monteregie]
Aicha Hamid1, Maryse Guay, Jacques Lemaire
1Département des Sciences de la santé communautaire, Université de Sherbrooke, Longueuil, QC. a.hamid@rrsss16.gouv.qc.ca
Insights
New vaccine schedules may cause slight delays in DTaP-P-Hib vaccine administration for younger children. Most parents prefer multiple injections per visit but have concerns about vaccine safety.
Area of Science:
- Pediatrics
- Immunization
- Public Health
Background:
- Vaccination schedules are crucial for child health.
- Recent updates to vaccine schedules may impact administration and parental perceptions.
- Understanding parental opinions on multiple injections is vital for public health initiatives.
Purpose of the Study:
- To assess the impact of new vaccine schedules on adherence.
- To explore parental opinions regarding multiple vaccine injections during a single visit.
Main Methods:
- A descriptive, cross-sectional study utilizing self-administered questionnaires.
- Two cohorts of children (2002-2003 and 2004-2005) were surveyed.
- Vaccine data were verified with existing records.
Main Results:
- The 2nd and 3rd doses of DTaP-P-Hib vaccine were administered late in younger children (median 2 and 4 days late, respectively).
- 76% of parents favored receiving 2-3 injections in one visit.
- 61% of parents expressed concerns about increased side effect risks with multiple vaccines.
Conclusions:
- While observed delays in vaccine administration have minimal public health impact, parental concerns regarding the safety of multiple vaccines require addressing.
- Reassurance and education are necessary to improve parental confidence in updated vaccination schedules and multiple injection protocols.
Objective:
This study aimed to explore the impact of adding new vaccines on schedule adherence and parental opinion of multiple injections.
Method:
A descriptive cross-sectional study by self-administered questionnaire mailed to a stratified random sample of each of two cohorts of children drawn from the Montérégie Birth Register: the 2002-2003 cohort (old vaccination schedule) and the 2004-2005 cohort (new schedule). Two surveys were done: Survey 1 (fall 2005-winter 2006) questioned parents whose address could be validated by Canada411.ca; Survey 2 (fall 2006) surveyed parents whose address was validated by the Quebec health insurance board (RAMQ). Incomplete or missing vaccine data were completed by verifying the vaccinators' files.
Results:
Analysis of schedule adherence by the Kaplan-Meier survival approach showed that the 2nd and 3rd doses of the DTaP-P-Hib vaccine were received late by the youngest children compared to the oldest (median number of days late: 2 days for the 2nd vaccine (p = 0.013) and 4 days for the 3rd vaccine (p < 0.001)). Many parents (76%) prefer 2 to 3 injections during a single visit, and 61% fear an increase in the risk of side effects.
Conclusion:
Even if the evaluated lateness has only a small public health impact, parents must be reassured about the safety of multiple vaccines.
Related Concept Videos
Vaccinations
Vaccines
Bioavailability Study Design: Single Versus Multiple Dose Studies
Drug Accumulation During Multiple Dosing: Repetitive IV Injections
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
