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Updated: Jun 14, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
[Effects of perinatal exposure to sulphamethazine on the thyroid gland function of SD rats]
Jintao Wang1, Ding Sun, Yunliang Qiu
1Department of Environmental Health, West China School of Public Health, China. wangjt620@126.com
Objective:
To study the effect of perinatal exposure sulphamethazine on the function of thyroid gland of SD rats.
Methods:
Dams were given sulphamethazine 0, 50, 100 and 200 mg/(kg x d) respectively from gestational day (GD) 7 to postpartum day (P) 21. The sections of thyroid gland of pups 20 days after birth were stained by hematoxylin-eosin, and the expression of proliferating cell nuclear antigen (PCNA) were observed by immunohistochemistry staining.
Results:
Compare with control, thyroid gland showed proliferation of follicular epithelium in each experimental group, and the numbers of PCNA positive cells in thyroid gland significantly higher than that of control (P < 0.05).
Conclusion:
Perinatal exposure to sulphamethazine may affect the function of thyroid gland of offspring.
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