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Related Experiment Video

Updated: Jun 14, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Multiple myeloma presenting with multiple thoracic manifestations.

L Fekih1, S Fenniche, H Hassene

  • 1Ibn Nafiss Division, Abderrahmen Mami Hospital, Ariana, Tunisia. leila.fekih@laposte.net

The Indian Journal of Chest Diseases & Allied Sciences
|April 7, 2010
PubMed
Summary

This case report details thoracic involvement in multiple myeloma, a plasma cell cancer. The patient presented with symptoms like chest pain and dyspnea, ultimately succumbing to the disease.

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Area of Science:

  • Oncology
  • Hematology
  • Pulmonology

Background:

  • Multiple myeloma is a plasma cell malignancy primarily affecting bone marrow.
  • Extramedullary involvement can occur, impacting various organs.
  • Thoracic manifestations are less common but significant.

Observation:

  • A 61-year-old non-smoking woman presented with chest pain, dyspnea, and cough.
  • Symptoms indicated progressive deterioration over seven months.
  • Clinical presentation suggested significant thoracic pathology.

Findings:

  • The patient exhibited left-sided pleural effusion, osseous lesions, bronchial infiltration, and mediastinal lymphadenopathy.
  • Serum and pleural fluid analysis revealed elevated kappa-light chain immunoglobulin G (IgG).
  • Biopsies confirmed myelomatous infiltration of the bronchi and pleura; bone marrow showed extensive plasma cell infiltration.

Implications:

  • This case highlights the diverse clinical presentations of multiple myeloma.
  • Thoracic involvement can significantly impact patient morbidity and mortality.
  • Early recognition and management of extramedullary disease are crucial in multiple myeloma care.