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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Blood Typing01:10

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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Blood transfusions in critical care: improving safety through technology & process analysis.

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Related Experiment Video

Updated: Jun 14, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Interdisciplinary process improvement for enhancing blood transfusion safety.

Mark LaRocco1, Kathy Brient

  • 1St. Luke's Episcopal Hospital, Houston, TX, USA. mlarocco@sleh.com

Journal for Healthcare Quality : Official Publication of the National Association for Healthcare Quality
|April 7, 2010
PubMed
Summary

This study enhanced blood transfusion safety through a multidisciplinary approach, implementing new technologies and LEAN process improvements. These efforts significantly reduced transfusion errors, improving patient safety in our hospital.

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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

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Last Updated: Jun 14, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

Area of Science:

  • Healthcare Improvement
  • Patient Safety
  • Transfusion Medicine

Background:

  • Blood transfusions are critical but carry inherent risks.
  • System-wide practices in blood product management require continuous improvement.
  • Reducing transfusion errors is essential for patient safety.

Purpose of the Study:

  • To implement a comprehensive, multidisciplinary strategy to enhance blood transfusion safety.
  • To systematically address all phases of the transfusion cycle, from ordering to post-transfusion documentation.
  • To reduce the incidence of transfusion errors within a hospital setting.

Main Methods:

  • A multipronged, multidisciplinary effort was undertaken.
  • New technologies and LEAN process improvement techniques were applied.
  • Practices were optimized across ordering, labeling, transportation, verification, and documentation.

Main Results:

  • Significant reduction in the risk of transfusion error achieved.
  • Improved system-wide practices in blood product management implemented.
  • Enhanced patient safety through a more secure transfusion process.

Conclusions:

  • A systematic, technology-driven, and process-focused approach effectively improves blood transfusion safety.
  • Multidisciplinary collaboration is key to successful implementation of safety initiatives.
  • Reducing transfusion errors leads to better patient outcomes and healthcare quality.