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[Factors contributing to gallstone formation and their interaction]
Aim:
to study factors contributing to gallstone formation and to elucidate their relationship.
Subjects And Methods:
The examination of 230 patients with various hepatobiliary abnormalities used dynamic ultrasonic cholecystography, multifractional duodenal intubation, followed by a microscopic study and determination of the physicochemical properties of bile. Enzyme immunoassay was employed to measure the peripheral blood levels of gastrin, insulin, T3, T4, thyroid-stimulating hormone, cortisol, and growth hormone.
Results:
All the patients were found to have signs of an early (gallstone pre-formation) stage of cholelithiasis. Decreased emptying of the gallbladder and its hypotonia and altered bile physicochemical properties were ascertained to be poor predictors of possible gallstone formation.
Conclusion:
Correlation analysis has shown the important role of hormonal factors in the formation of lithogenic bile.
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