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Updated: Jun 14, 2026

Visualizing the DNA Damage Response in Purkinje Cells Using Cerebellar Organotypic Cultures
Published on: December 27, 2024
Cellular automaton model of damage
C A Serino1, W Klein, J B Rundle
1Department of Physics, Boston University, Boston, Massachusetts 02215, USA. cserino@physics.bu.edu
Abstract:
We investigate the role of equilibrium methods and stress transfer range in describing the process of damage. We find that equilibrium approaches are not applicable to the description of damage and the catastrophic failure mechanism if the stress transfer is short ranged. In the long-range limit, equilibrium methods apply only if the healing mechanism associated with ruptured elements is instantaneous. Furthermore we find that the nature of the catastrophic failure depends strongly on the stress transfer range. Long-range transfer systems have a failure mechanism that resembles nucleation. In short-range stress transfer systems, the catastrophic failure is a continuous process that, in some respects, resembles a critical point.
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