Dynamics of coupled adaptive elements: bursting and intermittent oscillations generated by frustration in networks

Adaptation to environmental change is a common property of biological systems. Cells initially respond to external changes in the environment, but after some time, they regain their original state. By considering an element consisting of two variables that show such adaptation dynamics, we studied a coupled dynamical system containing such elements to examine the diverse dynamics in the system and classified the behaviors on the basis of the network structure that determined the interaction among elements. For a system with two elements, two types of behaviors, perfect adaptation and simple oscillation, were observed. For a system with three elements, in addition to these two types of dynamics, rapid-burst-type oscillation and a slow cycle were discovered; depending on the initial conditions, these two types of dynamics coexisted. These behaviors are a result of the characteristic dynamics of each element, i.e., fast response and slow adaptation processes. The behaviors depend on the network structure (in specific, a combination of positive or negative feedback among elements). Cooperativity among elements due to a positive feedback loop leads to simple oscillation, whereas frustration involving alternating positive and negative interactions among elements leads to the coexistence of rapid bursting oscillation and a slow cycle. These behaviors are classified on the basis of the frustration indices defined by the network structure. The period of the slow cycle is much longer than the original adaptation time scale, while the burst-type oscillation is a continued response that does not involve any adaptation. We briefly discuss the universal applicability of our results to a network of a larger number of elements and their possible relevance to biological systems.