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A case of cerebellar medulloblastoma with a single chromosome abnormality
M R Stratton1, J Darling, C S Cooper
1Department of Neuropathology, Institute of Psychiatry, London, England.
Cancer Genetics and Cytogenetics
|May 1, 1991
Abstract:
In the few published karyotypes of human medulloblastoma, multiple chromosome abnormalities have usually been demonstrated. We report a case of medulloblastoma in which only a single structural alteration was observed, namely an unbalanced translocation between chromosomes 1 and 6 resulting in partial 1q trisomy and partial 6q mónosomy. This finding may help define genomic regions that are of importance in development of medulloblastoma.