Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Molecular-level insights into the therapeutic potential of lidocaine: effects on proliferation, autophagy, and cellular impedance in human oral cells.

BMC oral health·2026

Same author

Robust neurogenesis in chronic stroke monkeys following mesenchymal stem cell transplantation plus intermittent theta-burst stimulation.

Signal transduction and targeted therapy·2026

Same author

Fully tunable optical filter based on a thin-film lithium niobate microring resonator.

Optics letters·2026

Same author

Early temporary ventricular assist device intervention improves survival in fulminant myocarditis with cardiogenic shock: experience from a single centre and national cohort.

Frontiers in cardiovascular medicine·2026

Same author

Efficacy and Safety of Radiotherapy Combined with PD-1 Inhibitors and Targeted Therapy for Unresectable Hepatocellular Carcinoma: A Retrospective, Real-World Multicenter Study.

Journal of hepatocellular carcinoma·2026

Same author

Forward Brillouin scattering in non-suspended lithium niobate waveguides at visible wavelengths.

Optics letters·2026

Search research articles

Related Experiment Video

Updated: Jun 14, 2026

Generation of Induced Pluripotent Stem Cell-Derived iTenocytes via Combined Scleraxis Overexpression and 2D Uniaxial Tension

Generation of Induced Pluripotent Stem Cell-Derived iTenocytes via Combined Scleraxis Overexpression and 2D Uniaxial Tension

Published on: March 1, 2024

Stem cells for tendon tissue engineering and regeneration.

Zi Yin¹, Xiao Chen, Jia-Lin Chen

¹Zhejiang University, School of Medicine, Center for Stem Cell and Tissue Engineering, Mailbox #39, 388 Yu Hang Tang Road, Hangzhou 310058, China.

Expert Opinion on Biological Therapy

|April 7, 2010

Summary

This summary is machine-generated.

This review explores strategies for tendon regeneration using stem cells, focusing on growth factors, scaffolds, and stimulation. Advances in tissue engineering offer hope for repairing challenging tendon injuries.

More Related Videos

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Published on: March 22, 2024

Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells

Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells

Published on: August 1, 2020

Related Experiment Videos

Last Updated: Jun 14, 2026

Generation of Induced Pluripotent Stem Cell-Derived iTenocytes via Combined Scleraxis Overexpression and 2D Uniaxial Tension

Generation of Induced Pluripotent Stem Cell-Derived iTenocytes via Combined Scleraxis Overexpression and 2D Uniaxial Tension

Published on: March 1, 2024

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Published on: March 22, 2024

Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells

Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells

Published on: August 1, 2020

Area of Science:

Regenerative Medicine
Biomaterials Science
Stem Cell Biology

Background:

Tendon injuries are prevalent in sports, yet tendons possess limited self-repair capacity.
Stem cell biology and tissue engineering offer promising avenues for tissue regeneration.
Stem cells, with their multipotency and self-renewal, are ideal for tissue engineering applications.

Purpose of the Study:

To review strategies for directing stem cell differentiation towards tendon lineage.
To explore methods for complete tendon regeneration using engineered stem cells.
To highlight the potential of embryonic stem cells in tendon tissue engineering.

Main Methods:

Review of inductive growth factors, bio-scaffolds, mechanical stimulation, and genetic modification.
Discussion of co-culture techniques for directing stem cell differentiation.
Analysis of regulating stem cell microenvironments with chemical and physical signals.

Main Results:

Encouraging results have been achieved using embryonic stem cells for tendon tissue engineering.
The combination of environmental cues can induce stem cell differentiation into tendon cells.
Summary of fundamental questions and future research directions in tendon biology and engineering.

Conclusions:

Multifaceted technologies are crucial for controlling stem cell differentiation.
Novel stem cell-based therapies are needed for effective tendon repair.
Advanced approaches are essential for achieving complete regeneration of injured tendons.