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Updated: Jun 14, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
Dysregulation in T helper 1/T helper 2 cytokine ratios in patients with multiple myeloma
Alpana Sharma1, Rehan Khan, Suhasini Joshi
1Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India. dralpanasharma@gmail.com
Abstract:
We have assessed alterations of Th1 and Th2 derived cytokines in the progression of multiple myeloma (MM) by determining their circulatory concentrations in patients with MM and healthy controls and correlated observations with grade and severity of the disease. The study group consisted of 112 subjects: 62 patients with MM and 50 healthy controls. Regarding serum levels of Th1 cytokines, IFN-gamma was significantly lower and IL-2 was non-significantly increased, while regarding levels of Th2 cytokines, IL-4 and IL-10 were significantly elevated. Results of our study indicate that a marked polarization exists toward Th2 cytokines in MM while Th1 cytokines remain suppressed.
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