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Related Experiment Video

Updated: Jun 14, 2026

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Published on: November 4, 2016

Dendritic cells in systemic lupus erythematosus.

Heather M Seitz¹, Glenn K Matsushima

¹Johnson County Community College, Science Division, Overland Park, Kansas, USA.

International Reviews of Immunology

|April 7, 2010

Summary

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. This study explores the role of dendritic cells (DCs) and innate immunity in regulating autoreactive B cells in SLE.

Area of Science:

Immunology
Autoimmunity
Rheumatology

Background:

Systemic lupus erythematosus (SLE) is a complex, chronic autoimmune disease.
SLE pathogenesis involves genetic susceptibility and environmental factors.
Existing research extensively covers cytokines, chemokines, B cells, and T cells in SLE.

Purpose of the Study:

To investigate the role of dendritic cells (DCs) in SLE.
To explore the involvement of innate immune factors in regulating autoreactive B cells in SLE.

Main Methods:

Review of existing literature on SLE immunology.
Focus on dendritic cells and innate immune pathways.

Main Results:

Dendritic cells (DCs) play a crucial role in immune regulation.

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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

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Published on: November 1, 2015

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Last Updated: Jun 14, 2026

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Published on: November 4, 2016

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Innate immune factors contribute to the control of autoreactive B cells.

Conclusions:

Dendritic cells and innate immunity are key regulators in SLE pathogenesis.
Targeting these pathways may offer therapeutic strategies for SLE.