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Updated: Jun 14, 2026
07:40
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Pharmacotherapy of uveitis
Frank F Lee1, Charles Stephen Foster
1Massachusetts Eye Research and Surgery Institution, 5 Cambridge Center, 8th Floor, Cambridge, MA 02142, USA.
Expert Opinion on Pharmacotherapy
|April 7, 2010
Summary
Aggressively treat ocular inflammation (uveitis) to prevent vision loss. Steroid-sparing immunosuppressive therapy is preferred over long-term corticosteroids for uveitis management.
Area of Science:
- Ophthalmology
- Immunology
Background:
- Uveitis is a spectrum of ocular inflammation affecting the uveal tract.
- Severe uveitis requires aggressive treatment to prevent chronic inflammation-induced damage, including potential blindness.
Purpose of the Study:
- To review current treatment strategies for uveitis.
- To detail various medications, their appropriate uses, and side effect monitoring.
Main Methods:
- Discussion of corticosteroid formulations (topical, regional, oral, intravenous).
- Overview of immunomodulatory agents including antimetabolites, T-cell inhibitors, alkylating agents, and biologic response modifiers.
Main Results:
- A stepladder approach to ocular inflammation treatment is outlined.
- Corticosteroids are the primary treatment for acute flares.
- Steroid-free remission is achievable with chemotherapeutic agents.
Conclusions:
- Long-term systemic corticosteroid therapy is not recommended for uveitis unless other treatments fail.
- Steroid-sparing immunosuppressive therapy should be initiated after controlling acute uveitis flares.
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