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Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions
12:29

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Published on: May 23, 2011

S100B profiles and cognitive function at high altitude.

Henrik Bjursten1, Per Ederoth, Engilbert Sigurdsson

  • 1Department of Cardiothoracic Surgery, Department of Clinical Sciences, Lund University, Lund, Sweden. henrik.bjursten@med.lu.se

High Altitude Medicine & Biology
|April 7, 2010
PubMed
Summary
This summary is machine-generated.

High altitude exposure increases S100B protein, indicating potential blood-brain barrier changes, and correlates with cognitive decline in acute mountain sickness (AMS). This suggests S100B may be a marker for altitude-related neurological effects.

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Area of Science:

  • Neuroscience
  • Altitude Medicine
  • Physiology

Background:

  • High altitude exposure can cause acute mountain sickness (AMS) and high altitude cerebral edema (HACE).
  • S100B protein release is a potential indicator of blood-brain barrier (BBB) disruption.
  • Neurocognitive function can be affected by altitude, but the underlying mechanisms require further investigation.

Purpose of the Study:

  • To investigate the effect of high altitude on neurocognitive function.
  • To assess S100B protein release as a marker of BBB integrity during ascent to high altitude.
  • To explore the relationship between S100B levels, AMS symptoms, and neurocognitive performance.

Main Methods:

  • Seven healthy volunteers ascended to 4554 m.
  • Neurocognitive testing, Lake Louise Scoring (LLS), and blood sampling for S100B levels were performed at multiple altitudes.
  • Data analysis focused on changes from baseline and correlations between variables.

Main Results:

  • S100B levels increased significantly (42%–122%) from baseline at high altitude.
  • Mean LLS scores increased, indicating the development of AMS symptoms.
  • Significant correlations were found between S100B levels and LLS, and between S100B and certain neurocognitive scores.

Conclusions:

  • Mild hypoxia at high altitude can lead to S100B release, suggesting potential BBB alterations.
  • The correlation between S100B and reduced neurocognitive performance indicates a link between S100B elevation and cognitive impairment.
  • Cognitive function decline is associated with AMS symptoms during high-altitude exposure.