Related Experiment Video

Updated: Jun 14, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

[Relation between the level of serum CA19-9 and glucose control in inpatients with diabetes]

Hao-yong Yu1, Yu-qian Bao, Lei Zhang

  • 1Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai 200233, China.

Zhonghua Yi Xue Za Zhi
|April 7, 2010
PubMed

Insights

Elevated serum CA199 levels in diabetic patients are linked to poor glucose control, indicated by higher hemoglobin A1c (HbA1c) and glycated albumin (GA). HbA1c is an independent risk factor for increased CA199.

Area of Science:

  • Endocrinology
  • Clinical Chemistry
  • Oncology Biomarkers

Background:

  • Diabetes mellitus is a chronic metabolic disorder.
  • Glycemic control is crucial for managing diabetes complications.
  • CA199 is a tumor-associated antigen, but its elevation in non-malignant conditions like diabetes is of interest.

Purpose of the Study:

  • To investigate the association between glycemic control markers (HbA1c, GA) and serum CA199 levels in diabetic patients.
  • To determine if HbA1c or GA are independent predictors of CA199.

Main Methods:

  • A cross-sectional study involving 371 diabetic patients and 29 healthy controls.
  • Patients were stratified into groups based on HbA1c levels (<6.5%, 6.5%-7.5%, >7.5%).
  • Serum CA199, HbA1c, glycated albumin (GA), and other clinical parameters were analyzed using correlation and multiple stepwise regression.

Main Results:

  • Serum CA199 levels were significantly higher in diabetic patients with HbA1c >7.5% compared to other groups.
  • CA199 showed a positive correlation with HbA1c (r=0.394) and GA (r=0.381).
  • Multiple regression analysis identified HbA1c as an independent risk factor for elevated CA199.

Conclusions:

  • Poor glycemic control in diabetes is associated with elevated serum CA199.
  • CA199 levels correlate positively with markers of long-term and short-term glycemic control (HbA1c and GA).
  • Hemoglobin A1c is an independent predictor of elevated CA199 in diabetic patients.
Abstract

Related Concept Videos

Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...