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[Influencing factors for cerebral microbleeds in patients with acute ischemic stroke]

Zhi-Ming Zhou1, Song Yang, Xuan-Ye Yue

  • 1Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.

Zhonghua Yi Xue Za Zhi
|April 7, 2010
PubMed
Abstract

Insights

Cerebral microbleeds (CMB) are common in acute ischemic stroke patients. High plasma fibrinogen levels are strongly associated with the presence of CMB, indicating a significant relationship.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Biochemistry

Context:

  • Acute ischemic stroke presents a significant health challenge.
  • Cerebral microbleeds (CMB) are increasingly recognized as a marker of cerebrovascular disease.
  • Understanding factors associated with CMB is crucial for stroke management.

Purpose:

  • To investigate the association between cerebral microbleeds (CMB) and cardiovascular risk factors, specifically plasma fibrinogen levels, in patients experiencing acute ischemic stroke.

Summary:

  • A prospective study of 68 acute ischemic stroke patients found that 43% had cerebral microbleeds (CMB) detected via MRI.
  • Significant associations were observed between CMB presence and age, hypertension, plasma fibrinogen, and uric acid levels.
  • Logistic regression analysis confirmed age, hypertension, and plasma fibrinogen as independent predictors of CMB.

Impact:

  • This study highlights the high prevalence of CMB in acute ischemic stroke.
  • Findings underscore the critical link between elevated plasma fibrinogen and cerebral microbleeds, suggesting potential therapeutic targets.

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