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Related Concept Videos

Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
Cardiac Catheterization II: Right Heart Catheterization01:21

Cardiac Catheterization II: Right Heart Catheterization

Right Heart Catheterization: An OverviewRight heart catheterization is an invasive diagnostic procedure that measures right-sided cardiac and pulmonary artery pressures, calculates cardiac output, and identifies intracardiac shunts. It provides detailed hemodynamic data essential for diagnosing and managing various cardiovascular conditions, such as pulmonary hypertension.Access SitesCommon access sites for right heart catheterization include the internal jugular vein in the neck region, the...
Cardiac Catheterization IV: Nursing Management01:26

Cardiac Catheterization IV: Nursing Management

Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...
Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...

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Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
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Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Published on: January 22, 2011

The CATH database.

Michael Knudsen1, Carsten Wiuf

  • 1Bioinformatics Research Centre, Aarhus University, DK-8000 Aarhus C, Denmark.

Human Genomics
|April 7, 2010
PubMed
Summary
This summary is machine-generated.

The CATH database classifies protein domains by folding patterns using manual and automated methods. Its website offers easy access to this protein structure data for browsing and downloading.

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Area of Science:

  • Structural bioinformatics
  • Protein domain classification

Background:

  • Protein domains are fundamental units of protein structure and function.
  • Hierarchical classification aids in understanding evolutionary relationships and structural similarities.
  • The Protein Data Bank (PDB) is a primary repository for protein structure data.

Purpose of the Study:

  • To review the CATH database, a resource for hierarchical protein domain classification.
  • To highlight the methods used for domain identification and classification.
  • To introduce the accompanying website and associated tools for data access.

Main Methods:

  • Hierarchical classification of protein domains based on structural folding patterns.
  • Utilizing data from the Protein Data Bank (PDB).
  • Employing both manual and automated procedures for domain identification and classification.

Main Results:

  • The CATH database offers a structured classification of protein domains.
  • The classification is based on identified folding patterns.
  • Both manual and automated methods contribute to the database's accuracy and comprehensiveness.

Conclusions:

  • The CATH database provides a valuable, hierarchical classification of protein domains.
  • The associated website (www.cathdb.info) facilitates user-friendly access, browsing, and data downloading.
  • The database and its tools support research in structural biology and bioinformatics.