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Apo-B/AI ratio identifies cardiovascular risk in childhood: the Australian Aboriginal Birth Cohort study

Elizabeth A C Sellers1, Gurmeet R Singh, Susan M Sayers

  • 1Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada. esellers@exchange.hsc.mb.ca

Diabetes & Vascular Disease Research
|April 7, 2010
PubMed

Insights

The apolipoprotein B/A1 ratio may help identify cardiovascular risk in Australian Aboriginal children. This ratio is linked to higher obesity and metabolic syndrome prevalence in boys and girls.

Area of Science:

  • Cardiovascular Health
  • Pediatric Health
  • Indigenous Health

Background:

  • Cardiovascular disease risk factors are a concern in Indigenous populations.
  • Understanding lipoprotein and apolipoprotein profiles is crucial for early risk identification in children.

Purpose of the Study:

  • To examine lipoprotein and apolipoprotein profiles in Australian Aboriginal children.
  • To investigate the relationship between these profiles and cardiovascular risk factors.

Main Methods:

  • Cross-sectional analysis of a longitudinal birth cohort study (children born 1987-1990, re-examined 1998-2001).
  • Measured height, weight, blood pressure, waist circumference, body fat percentage, cholesterol, triglycerides, HDL-c, LDL-c, apolipoprotein B, and apolipoprotein A1.
  • Analyzed the apolipoprotein B/A1 ratio in relation to obesity and metabolic syndrome prevalence.

Main Results:

  • No significant differences in mean cholesterol, triglyceride, HDL-c, or LDL-c compared to reference data.
  • Boys with a high Apo-B/A1 ratio showed increased BMI z-score, waist z-score, body fat, diastolic blood pressure, and metabolic syndrome prevalence.
  • Girls with a high Apo-B/A1 ratio had higher waist circumference, body fat, and metabolic syndrome prevalence.

Conclusions:

  • The apolipoprotein B/A1 ratio may serve as a valuable tool for identifying cardiovascular risk in Australian Aboriginal children.
  • This ratio is suitable for clinical practice due to standardized, accurate, automated assays that do not require fasting.

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