Metabolic syndrome, endothelial function and lifestyle modification.
Kunihiko Aizawa1, J Kevin Shoemaker, Tom J Overend
1Lawson Health Research Institute, London, Canada.
Diabetes & Vascular Disease Research
|April 7, 2010
Summary
Metabolic syndrome (MS) did not impair endothelial function in individuals at high cardiovascular risk. A 24-week lifestyle intervention improved some MS components but did not significantly alter endothelial function.
Area of Science:
- Cardiovascular disease research
- Metabolic syndrome studies
- Endothelial function analysis
Background:
- Metabolic syndrome (MS) is linked to increased cardiovascular disease (CVD) risk.
- Endothelial dysfunction is an early marker of atherosclerosis.
- Individuals with hypertension (HNBP) and/or impaired glucose regulation (IGR) are at elevated CVD risk.
Purpose of the Study:
- To assess endothelial function cross-sectionally in subjects with and without MS.
- To examine the impact of a 24-week lifestyle modification program on endothelial function in subjects with MS.
Main Methods:
- Cross-sectional evaluation of endothelial function (flow-mediated dilation [FMD], ICAM-1, VCAM-1) in subjects with (MS+) and without (MS-) metabolic syndrome.
- Assessment of MS components, FMD via Doppler ultrasound, and ICAM-1/VCAM-1 levels from fasting blood samples.
- Intervention group received 24-week lifestyle modification.
Main Results:
- No significant differences in endothelial function (FMD, ICAM-1, VCAM-1) were observed between MS+ and MS- groups.
- Lifestyle modification led to improvements in waist circumference, blood pressure, and fasting glucose in MS+ subjects.
- Endothelial function parameters remained unchanged after the 24-week intervention in the MS+ group.
Conclusions:
- Metabolic syndrome, in this population at high CVD risk, was not associated with reduced endothelial function.
- A 24-week lifestyle modification program did not improve endothelial function in subjects with MS, despite improvements in certain metabolic parameters.
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