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Published on: March 28, 2025
Metabolic shifts in immunity and inflammation
Douglas J Kominsky1, Eric L Campbell, Sean P Colgan
1Department of Anesthesiology, University of Colorado Denver Health Sciences Center, Aurora, CO 80045, USA.
Journal of Immunology (Baltimore, Md. : 1950)
|April 7, 2010
Summary
Inflammation and immune responses significantly alter tissue metabolism, driven by immune cell activity and leading to hypoxia. These metabolic shifts can fundamentally change tissue characteristics and function.
Area of Science:
- Immunology
- Metabolic Biology
- Cellular Physiology
Background:
- Inflammation and immune responses involve significant metabolic activity changes in tissues.
- These metabolic shifts are driven by immune cell recruitment (neutrophils, monocytes) and lymphocyte proliferation.
- Metabolic changes can lead to acidosis and hypoxia, altering tissue phenotype.
Purpose of the Study:
- To review recent research on metabolic changes during inflammation and immunity.
- To explore the role of metabolic control in regulating inflammatory and immune processes.
Main Methods:
- Literature review of recent studies.
- Analysis of metabolic shifts in inflammatory and immune contexts.
- Examination of hypoxia-induced transcriptional and translational changes.
Main Results:
- Inflammation triggers substantial metabolic reprogramming in affected tissues.
- Immune cell populations dynamically alter local energy metabolism.
- Hypoxia resulting from metabolic shifts induces significant phenotypic changes in tissues.
Conclusions:
- Metabolic changes are integral to the inflammatory and immune response.
- Understanding metabolic control offers therapeutic targets for immune and inflammatory diseases.
- Tissue metabolic reprogramming has lasting effects on cellular phenotype.
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