Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Friedman Two-way Analysis of Variance by Ranks01:21

Friedman Two-way Analysis of Variance by Ranks

Friedman's Two-Way Analysis of Variance by Ranks is a nonparametric test designed to identify differences across multiple test attempts when traditional assumptions of normality and equal variances do not apply. Unlike conventional ANOVA, which requires normally distributed data with equal variances, Friedman's test is ideal for ordinal or non-normally distributed data, making it particularly useful for analyzing dependent samples, such as matched subjects over time or repeated measures from...
Randomized Experiments01:13

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Survival Tree01:19

Survival Tree

Survival trees are a non-parametric method used in survival analysis to model the relationship between a set of covariates and the time until an event of interest occurs, often referred to as the "time-to-event" or "survival time." This method is particularly useful when dealing with censored data, where the event has not occurred for some individuals by the end of the study period, or when the exact time of the event is unknown.
 Building a Survival Tree
Constructing a survival tree begins...
Methods of Medium Optimization01:28

Methods of Medium Optimization

Optimizing growth media enhances microbial proliferation and maximizes product yield. Statistical experimental design methodologies provide structured and reproducible approaches, offering progressively higher levels of robustness and efficiency.The One-Factor-at-a-Time (OFAT) MethodThe One-Factor-at-a-Time (OFAT) method involves adjusting a single variable while keeping all others constant. However, it cannot detect interactions between variables, often leading to suboptimal outcomes when...
Statistical Inference Techniques in Hypothesis Testing: Parametric Versus Nonparametric Data01:16

Statistical Inference Techniques in Hypothesis Testing: Parametric Versus Nonparametric Data

Statistical inference techniques, paramount in hypothesis testing, differentiate into two broad categories: parametric and nonparametric statistics.
Parametric statistics, as the name suggests, assumes that data follow a specific distribution, often a normal distribution. This assumption enables robust hypothesis testing and estimation. Parametric methods, like the Student's t-test or Goodness-of-fit test, are frequently employed in biostatistics due to their robustness. For instance, comparing...
Bonferroni Test01:10

Bonferroni Test

The Bonferroni test is a statistical test named after Carlo Emilio Bonferroni, an Italian mathematician best known for Bonferroni inequalities. This statistical test is a type of multiple comparison test to determine which means are different than the rest. Bonferroni test can minimize the Type 1 error by reducing the significance level alpha, which otherwise increases with sample pairs.
The means of different samples are first paired in all possible combinations.
The null hypothesis of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells.

Cardiovascular research·2010
Same author

In vitro and in vivo antitumor effects of novel actinomycin D analogs with amino acid substituted in the cyclic depsipeptides.

Peptides·2010
Same author

[Detection of single-walled carbon nanotube bundles by tip-enhanced Raman spectroscopy].

Guang pu xue yu guang pu fen xi = Guang pu·2009
Same author

Calcium-sensing receptors induce apoptosis in rat cardiomyocytes via the endo(sarco)plasmic reticulum pathway during hypoxia/reoxygenation.

Basic & clinical pharmacology & toxicology·2009
Same author

Evolution of the solvent polarity in an electrospray plume.

Journal of the American Society for Mass Spectrometry·2009
Same author

[The impact of platelet membrane autoantibodies on high-dose dexamethasone therapy in patients with idiopathic thrombocytopenic purpura].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2009
Same journal

Semiparametric regression methods for temporal processes subject to multiple sources of censoring.

The Canadian journal of statistics = Revue canadienne de statistique·2026
Same journal

Robust causal inference for point exposures with missing confounders.

The Canadian journal of statistics = Revue canadienne de statistique·2025
Same journal

Debiased lasso after sample splitting for estimation and inference in high-dimensional generalized linear models.

The Canadian journal of statistics = Revue canadienne de statistique·2025
Same journal

Variable selection in modelling clustered data via within-cluster resampling.

The Canadian journal of statistics = Revue canadienne de statistique·2025
Same journal

Robust Estimation of Loss-Based Measures of Model Performance under Covariate Shift.

The Canadian journal of statistics = Revue canadienne de statistique·2024
Same journal

Optimal multiwave validation of secondary use data with outcome and exposure misclassification.

The Canadian journal of statistics = Revue canadienne de statistique·2024
See all related articles

Related Experiment Video

Updated: Jun 14, 2026

Probing the Limits of Egg Recognition Using Egg Rejection Experiments Along Phenotypic Gradients
07:34

Probing the Limits of Egg Recognition Using Egg Rejection Experiments Along Phenotypic Gradients

Published on: August 22, 2018

Inference after variable selection using restricted permutation methods.

Rui Wang1, Stephen W Lagakos

  • 1Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.

The Canadian Journal of Statistics = Revue Canadienne De Statistique
|April 7, 2010
PubMed
Summary
This summary is machine-generated.

Researchers developed new statistical methods for analyzing data after variable selection, avoiding distorted inferences when using the same dataset for both selection and analysis. This improves the reliability of findings in observational studies.

Related Experiment Videos

Last Updated: Jun 14, 2026

Probing the Limits of Egg Recognition Using Egg Rejection Experiments Along Phenotypic Gradients
07:34

Probing the Limits of Egg Recognition Using Egg Rejection Experiments Along Phenotypic Gradients

Published on: August 22, 2018

Area of Science:

  • Statistics
  • Biostatistics
  • Data Analysis

Background:

  • Variable selection is common in analyzing multiple covariates and a response variable.
  • Standard inference methods can yield distorted results when applied to the same dataset used for variable selection.

Purpose of the Study:

  • To develop and validate statistical methods for inference on marginal associations after variable selection using the same dataset.
  • To provide reliable testing and interval estimation for model parameters.

Main Methods:

  • Development of novel testing and interval estimation methods for marginal association parameters.
  • Theoretical justification and simulation studies to assess performance.
  • Comparison with a sample-splitting approach.

Main Results:

  • The proposed methods provide valid inferences for parameters reflecting marginal associations after variable selection.
  • Simulations demonstrate the performance of the new methods compared to sample-splitting.
  • The methods are effective even when using the same dataset for selection and inference.

Conclusions:

  • The developed methods offer a robust solution for statistical inference in the presence of variable selection.
  • These techniques enhance the accuracy of findings from observational studies, as illustrated by an AIDS study example.