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Induction and Monitoring of Active Delayed Type Hypersensitivity (DTH) in Rats

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Published on: July 19, 2007

Delayed onset interstitial nephritis following multiple wasp stings.

J B Ghosh¹, M Roy, A K Bala

¹Department of Pediatric Medicine, Institute of Post-graduate Medical Education and Research, Kolkata, India.

Indian Journal of Nephrology

|April 7, 2010

Summary

Delayed hypersensitivity reactions from wasp stings are rare. This case report details a child experiencing acute interstitial nephritis after multiple wasp stings, a novel presentation in India.

Keywords:

Interstitial nephritis acute renal failure wasp sting

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Area of Science:

Immunology
Nephrology
Pediatrics

Background:

Delayed hypersensitivity reactions to insect stings are uncommon.
The exact immunological mechanism for delayed reactions remains unclear, but Type III hypersensitivity is suspected.
This involves immune complex deposition and complement system activation.

Observation:

A seven-year-old girl presented with symptoms of acute interstitial nephritis.
The nephritis occurred following multiple wasp stings.
This is the first reported case of such a delayed reaction in a child from India.

Findings:

The patient developed acute interstitial nephritis, a kidney condition.
The onset of nephritis was delayed after the wasp stings.
This represents a rare manifestation of hypersensitivity to wasp venom in pediatric patients.

Implications:

This case highlights a rare but serious potential complication of wasp stings in children.
Further research into the immunopathogenesis of delayed hypersensitivity reactions to insect stings is warranted.
Clinicians should consider delayed hypersensitivity reactions in children presenting with nephritis after insect exposure.