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Post transplant thrombotic microangiopathy causing acute renal failure

S Qutube1, K G Arun, N Jayaram

  • 1Department of Nephrology, NU Trust, Padmanabhanagar, Bangalore - 560 070, India.

Indian Journal of Nephrology
|April 7, 2010
PubMed

Insights

Acute Renal Failure (ARF) after kidney transplant is usually caused by specific conditions. This report highlights thrombotic microangiopathy as an unusual cause of ARF in the early post-transplant phase.

Area of Science:

  • Nephrology
  • Transplant Medicine
  • Pathology

Background:

  • Acute Renal Failure (ARF) is a common complication following kidney transplantation.
  • Typical causes include acute tubular necrosis, rejection, and drug toxicity, alongside prerenal and postrenal factors.

Observation:

  • This case report details an unusual etiology of ARF in the immediate post-transplant period.
  • The patient presented with symptoms indicative of a serious renal complication shortly after receiving a new kidney.

Findings:

  • The primary finding is the diagnosis of thrombotic microangiopathy (TMA) as the cause of ARF.
  • This contrasts with the more frequent causes of post-transplant ARF, presenting a diagnostic challenge.

Implications:

  • Recognizing TMA as a cause of post-transplant ARF is crucial for timely and appropriate management.
  • This case underscores the importance of considering less common pathologies in the differential diagnosis of early post-transplant renal dysfunction.
Keywords:
Acute renal failureanti phospho lipid antibody syndromerenal transplantthrombotic micro angiopathy

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