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Chronic urticaria--assessment and treatment
Suran Fernando1, Andrew Broadfoot
1Department of Clinical Immunology, Royal North Shore Hospital, St Leonards, New South Wales. sfernando@nsccahs.health.nsw.gov.au
Chronic urticaria, often idiopathic, requires careful history taking for diagnosis. Standard treatment involves second-generation antihistamines, with other options available for persistent cases.
Area of Science:
- Dermatology
- Immunology
- General Practice
Background:
- Chronic urticaria is a prevalent condition seen in primary care.
- It frequently leads to specialist referrals to immunology, allergy, and dermatology.
Purpose of the Study:
- To outline the assessment and management strategies for chronic urticaria.
- Focuses on the general practice setting.
Main Methods:
- Detailed patient history is crucial for diagnosis and identifying potential causes.
- Investigations like thyroid function tests are considered only when clinically indicated.
Main Results:
- Chronic urticaria is defined by wheals lasting over 6 weeks.
- In 80% of cases, the cause remains unidentified (chronic idiopathic urticaria).
- Allergic causes are uncommon; physical triggers, vasculitis, or systemic diseases are less frequent causes.
Conclusions:
- Second-generation antihistamines are the primary treatment, often requiring twice-daily dosing.
- Additional treatments such as H2 antagonists, doxepin, or immunomodulation may be needed for refractory cases.
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