Lab-on-a-Foil: microfluidics on thin and flexible films

Area of Science:

• Microfluidics
• Materials Science
• Biotechnology

Background:

• Growing interest in Lab-on-a-Chip (LOC) solutions utilizing thin and flexible films, termed Lab-on-a-Foil (LOF).
• LOF technology leverages diverse fabrication methods, including adaptations of macroscale processes and novel techniques.
• Flexible foils offer advantages like low thermal resistance for thermocycling and deformable chambers for reagent handling.

Purpose of the Study:

• To critically review materials, fabrication processes, and integration strategies for microfluidic functions in LOF devices.
• To analyze the current state of LOF applications, with a focus on specific diagnostic areas.
• To highlight the versatility and potential of the LOF approach in expanding LOC capabilities.

Main Methods:

• Review of existing literature on materials and fabrication techniques for flexible microfluidics.
• Analysis of integration methods for microfluidic components such as liquid control, transport, and reagent storage.
• Survey and categorization of current LOF applications in diagnostics and testing.

Main Results:

• Identification of a wide array of materials and fabrication processes suitable for LOF development.
• Demonstration of effective integration of microfluidic functions, including precise liquid handling and reagent release.
• Compilation of diverse applications, particularly in nucleic acid analysis, immunoassays, cell-based assays, and home care testing.

Conclusions:

• The Lab-on-a-Foil approach is highly versatile, offering significant advantages in cost-effectiveness and functionality.
• LOF technology substantially broadens the scope of Lab-on-a-Chip solutions, enabling novel applications.
• This review underscores the potential of flexible film-based microfluidics for high-volume, disposable diagnostic devices.