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Updated: Jun 14, 2026

Microscopic Cyst Resection for the Treatment of Patients Diagnosed with Epididymal Cyst
Published on: March 31, 2023
[Epididymal cyst in von Hippel-Lindau syndrome: clinicopathologic analysis of 3 cases]
Zhu Hou1, Yong Luo, Yong-Guang Jiang
1Department of Urology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, China. houzhuanzhen@sohu.com
Objective:
To investigate the clinicopathologic features of epididymal cyst in von Hippel-Lindau (VHL) syndrome.
Methods:
We reviewed the clinical data of 3 epididymal cyst patients treated by surgery, and detected the expressions of HIF-1alpha, VEGF, alpha-SMA and CD34 in the epididymal tissue samples by the immunohistochemistry SP method.
Results:
All the 3 patients underwent surgical removal of the epididymal cyst. Immunohistochemistry of the epididymal tissues showed HIF-1alpha, VEGF, alpha-SMA and CD34 to be positive. All the 3 cases were confirmed to be VHL syndrome, 1 right after surgery, and the other 2 within 8 years postoperatively.
Conclusion:
Epididymal cyst is a usual benign disease, which may occur independently of or be complicated by VHL syndrome. If immunohistochemistry of epididymal tissues shows HIF-1alpha, VEGF, alpha-SMA and CD34 to be positive, VHL syndrome should be considered, and further clinical examinations and post-operation follow-up are necessitated.
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