Mathematical analysis of a modular network coordinating the cell cycle and apoptosis
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Updated: Jun 14, 2026

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
Published on: September 26, 2025
Gheorghe Craciun1, Baltazar Aguda, Avner Friedman
1Mathematical Biosciences Institute, Ohio State University, 125 W. 18th Avenue, Columbus, OH 43210. gcraciun@mbi.ohio-state.edu.
Abstract:
The cell-division cycle and apoptosis are key cellular processes deregulated during carcinogenesis. Recent work of Aguda and Algar suggests a modular organization of regulatory molecular pathways linking the cellular processes of division and apoptosis. We carry out a detailed mathematical analysis of the Aguda-Algar model to unravel the dynamics implicit in the model structure. In addition, we further explore model parameters that control the bifurcations corresponding to the aforementioned cellular state tran- sitions. We show that this simple model predicts interesting behavior, such as hysteretic oscillations and different conditions in which apoptosis is triggered.
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