Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatially Resolved Heterogeneity of Lymphatic Vasculature in the Adult Lung-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

Viscoelastic recovery times of chondrocytes measured using a novel 3D-printed microfluidic device.

Measurement science & technology·2025
Same author

Somatic <i>Miwi2</i> modulates mitochondrial function in airway multiciliated cells and exacerbates influenza pathogenesis.

iScience·2025
Same author

A randomised crossover trial of daridorexant for the treatment of chronic insomnia and nocturia.

Journal of sleep research·2025
Same author

An appetitive olfactory learning paradigm for zebrafish in their home tanks.

Behavioural brain research·2025
Same author

Lung CD4<sup>+</sup> resident memory T cells use airway secretory cells to stimulate and regulate onset of allergic airway neutrophilic disease.

Cell reports·2025
Same journal

Modeling the impact of budget limitation on the screening and treatment pathway of HPV-induced precancerous cervical lesions.

Mathematical biosciences and engineering : MBE·2026
Same journal

Modeling the effects of trait-mediated dispersal on coexistence of two species: Competition and non-consumptive predator-prey.

Mathematical biosciences and engineering : MBE·2026
Same journal

A close look at the viral reduction rate in target cell limited models.

Mathematical biosciences and engineering : MBE·2026
Same journal

A stochastic agent-based model for simulating tumor-immune dynamics and evaluating therapeutic strategies.

Mathematical biosciences and engineering : MBE·2026
Same journal

Addressing domain shift via imbalance-aware domain adaptation in embryo development assessment.

Mathematical biosciences and engineering : MBE·2026
Same journal

Effect of drug resistance on an HIV epidemic in heterogeneous populations.

Mathematical biosciences and engineering : MBE·2026
See all related articles

Related Experiment Video

Updated: Jun 14, 2026

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms
08:28

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

Published on: March 3, 2023

Biological computing with diffusion and excitable calcium stores.

H G E Hentschel1, Alan Fine, C S Pencea

  • 1Department of Physics, Emory University Atlanta GA 30322. phshgeh@physics.emory.edu.

Mathematical Biosciences and Engineering : MBE
|April 8, 2010
PubMed
Summary
This summary is machine-generated.

This study explores how calcium stores in cells can perform computations using logic gates. It also shows how calcium release mechanisms can detect biological signals.

More Related Videos

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis
09:07

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis

Published on: February 18, 2020

Imaging Local Ca2+ Signals in Cultured Mammalian Cells
09:30

Imaging Local Ca2+ Signals in Cultured Mammalian Cells

Published on: March 3, 2015

Related Experiment Videos

Last Updated: Jun 14, 2026

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms
08:28

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

Published on: March 3, 2023

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis
09:07

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis

Published on: February 18, 2020

Imaging Local Ca2+ Signals in Cultured Mammalian Cells
09:30

Imaging Local Ca2+ Signals in Cultured Mammalian Cells

Published on: March 3, 2015

Area of Science:

  • Biophysics
  • Computational Biology
  • Cellular Signaling

Background:

  • Intracellular calcium (Ca2+) signaling is crucial for cellular functions.
  • Excitable calcium stores, coupled by diffusion, are common in cellular signaling pathways.
  • Understanding the computational potential of these signaling mechanisms is key to deciphering complex biological processes.

Purpose of the Study:

  • To investigate the computational capabilities of geometrically arranged excitable calcium stores.
  • To determine if these configurations can generate a complete set of logic gates.
  • To explore the application of calcium-induced calcium release (CICR) in building coincidence detectors for biological signals.

Main Methods:

  • Modeling of excitable calcium stores in various geometric arrangements.
  • Analysis of diffusion-coupled calcium dynamics.
  • Simulation of logic gate operations based on calcium release patterns.
  • Design principles for coincidence detectors using CICR.

Main Results:

  • Demonstrated that specific geometric configurations of excitable calcium stores can perform complete sets of logic gate operations.
  • Showcased the potential for intracellular calcium signaling to act as a computational substrate.
  • Established the feasibility of using the CICR mechanism for constructing biological coincidence detectors.

Conclusions:

  • Excitable calcium stores represent a versatile biological system capable of complex computation.
  • Geometric arrangement plays a critical role in the computational output of calcium signaling.
  • The CICR mechanism offers a promising avenue for developing novel biological sensors and computational devices.