Related Experiment Video
Updated: Jun 14, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Dynamic multidrug therapies for hiv: optimal and sti control approaches
B M Adams1, H T Banks, Hee-Dae Kwon
1Center for Research in Scientific Computation, North Carolina State University, Raleigh, NC 27695. Department of Mathematics, North Carolina State University, Raleigh, NC 27695. bmadams3@unity.ncsu.edu.
Abstract:
We formulate a dynamic mathematical model that describes the interaction of the immune system with the human immunodeficiency virus (HIV) and that permits drug "cocktail " therapies. We derive HIV therapeutic strategies by formulating and analyzing an optimal control problem using two types of dynamic treatments representing reverse transcriptase (RT) in hibitors and protease inhibitors (PIs). Continuous optimal therapies are found by solving the corresponding optimality systems. In addition, using ideas from dynamic programming, we formulate and derive suboptimal structured treatment interruptions (STI)in antiviral therapy that include drug-free periods of immune-mediated control of HIV. Our numerical results support a scenario in which STI therapies can lead to long-term control of HIV by the immune response system after discontinuation of therapy.
More Related Videos
Related Concept Videos
Retrovirus Life Cycles
Therapeutic Drug Monitoring: Affecting Factors
Sexually Transmitted Infections
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Drug Therapy
Antianxiety Medications
Combined Effects of Drugs: Synergism
Such synergistic combinations...

