Related Experiment Video
Updated: Jun 14, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Computational analysis of an aortic valve jet with Lagrangian coherent structures
Shawn C Shadden1, Matteo Astorino, Jean-Frédéric Gerbeau
1Mechanical and Aerospace Engineering, Illinois Institute of Technology, Chicago, Illinois 60616, USA.
Abstract:
Important progress has been achieved in recent years in simulating the fluid-structure interaction around cardiac valves. An important step in making these computational tools useful to clinical practice is the development of postprocessing techniques to extract clinically relevant information from these simulations. This work focuses on flow through the aortic valve and illustrates how the computation of Lagrangian coherent structures can be used to improve insight into the transport mechanics of the flow downstream of the valve, toward the goal of aiding clinical decision making and the understanding of pathophysiology.
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