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Updated: Jun 14, 2026

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
Published on: January 12, 2024
A case of rapid progression and vision loss in a patient with primary intraocular lymphoma
Amit Sangave1, Lisa J Faia, Steven Yeh
1Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-1857, USA.
Purpose:
To describe an atypical case of primary intraocular lymphoma (PIOL) with rapid progression leading to vision loss and death.
Methods:
A 71-year-old woman with a history of PIOL presented with a sudden decline in vision. MRI, CSF cytology, and ocular examination 2 months prior were unremarkable.
Results:
Repeat MRI of the brain and orbits at this time revealed a 0.8 x 2.4-cm lesion of the left choroid plexus. LP revealed rare atypical B cells. The patient rapidly deteriorated and died a month later.
Conclusion:
Recognition of the potential for rapid progression and mortality in patients with PIOL is essential.
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