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Vitamin E-coated cellulose acetate dialysis membrane: long-term effect on inflammation and oxidative stress
L Takouli1, D Hadjiyannakos, P Metaxaki
1Nephrology Department, Amalia Fleming Hospital, Athens, Greece. ltakouli@yahoo.gr
Background:
Chronic inflammation and oxidative stress are prevalent in hemodialysis (HD) patients. We evaluated the long-term effect of a vitamin E-coated cellulose acetate (CAE) membrane on oxidative stress and inflammation.
Methods:
Nine patients were switched to CAE membrane for 3 months and then changed back to polysulfone (PS) membrane again for 6 months. Reactive oxygen metabolites and derivatives (d-ROMs), total antioxidant capacity (TAC) and superoxide dismutase (SOD) (oxidative stress biomarkers), high-sensitivity C-reactive protein (Hs-CRP), and interleukin-6 (IL-6) (inflammation biomarkers) were measured.
Results:
d-ROMs decreased and TAC rose significantly at the end of the study, whereas SOD increased rapidly and immediately after the end of CAE treatment. Hs-CRP and IL-6 levels were significantly lowered at the end of the study.
Conclusions:
Vitamin E supplementation by vitamin E-coated CAE dialysis membrane suppresses oxidative stress and inflammation.
