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Familial Mediterranean fever and membranous glomerulonephritis: report of a case

Mevlut Ceri1, Selman Unverdi, Mustafa Altay

  • 1Department of Nephrology, Ankara Education and Research Hospital, and Department of Pathology, Faculty of Medicine, Ankara University, Ankara, Turkey.

Renal Failure
|April 8, 2010
PubMed

Insights

Familial Mediterranean fever (FMF) can cause kidney problems. This study reports the first case of membranous glomerulonephritis in FMF patients, successfully treated with colchicine.

Area of Science:

  • Nephrology
  • Genetics
  • Rheumatology

Background:

  • Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder.
  • FMF involves recurrent fever and serositis, with potential kidney complications like amyloidosis.
  • Various glomerulopathies are rarely associated with FMF.

Observation:

  • This report details the first documented case of membranous glomerulonephritis (MGM) in a patient with FMF.
  • The patient experienced complete remission of MGM.

Findings:

  • Membranous glomerulonephritis is a newly identified kidney manifestation in FMF.
  • Colchicine treatment led to complete remission of the glomerulonephritis.

Implications:

  • This finding expands the spectrum of kidney diseases associated with FMF.
  • Colchicine may be an effective treatment for FMF-associated membranous glomerulonephritis.

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