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Updated: Jun 14, 2026
07:16
Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
Adenosine receptor ligands in clinical trials
Flavio Rizzolio1, Raffaele La Montagna, Tiziano Tuccinardi
1Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA.
Current Topics in Medicinal Chemistry
|April 8, 2010
Summary
Adenosine receptor research has yielded over 2000 drug compounds. Engineered mouse models are crucial for developing selective adenosine agonists and antagonists for various diseases.
Area of Science:
- Pharmacology
- Neuroscience
- Drug Discovery
Background:
- Adenosine and its receptors are vital in physiological and pathological states.
- Developing specific adenosine-targeting drugs is challenging due to widespread receptor expression and overlapping functions.
Purpose of the Study:
- To review the role of mouse models in understanding adenosine receptor function.
- To highlight adenosine receptor ligands currently in clinical trials for therapeutic applications.
Main Methods:
- Utilizing engineered mouse models to isolate and study individual adenosine receptor functions in specific tissues.
- Compiling data on over 2000 designed adenosine receptor compounds and their clinical trial status.
Main Results:
- Engineered mice have been instrumental in dissecting the roles of specific adenosine receptors.
- Over 2000 adenosine receptor-targeting compounds have been developed, with some progressing to clinical trials.
Conclusions:
- Mouse models are essential tools for advancing the development of selective adenosine receptor drugs.
- Significant progress has been made in identifying potential therapeutics for various pathologies targeting adenosine receptors.
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