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Related Concept Videos

Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...
Tissue Injury: Inflammation and Repair01:28

Tissue Injury: Inflammation and Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...

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Related Experiment Video

Updated: Jun 14, 2026

A Simplified Protocol for Protecting Palatal Soft Tissue Donor Sites Using an Oral Mucoadhesive Bandage
03:42

A Simplified Protocol for Protecting Palatal Soft Tissue Donor Sites Using an Oral Mucoadhesive Bandage

Published on: February 17, 2026

Soft tissue coverage of combat wounds.

Scott M Tintle1, David E Gwinn, Romney C Andersen

  • 1Orthopaedic Surgery Service, Bethesda, MD, USA.

Journal of Surgical Orthopaedic Advances
|April 8, 2010
PubMed
Summary
This summary is machine-generated.

Warfare-related extremity wounds with soft tissue defects can be successfully reconstructed using flap surgery, achieving high limb salvage rates (94%) even in the subacute period. This approach offers a viable solution for complex combat injuries.

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A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
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A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

Published on: July 4, 2019

Related Experiment Videos

Last Updated: Jun 14, 2026

A Simplified Protocol for Protecting Palatal Soft Tissue Donor Sites Using an Oral Mucoadhesive Bandage
03:42

A Simplified Protocol for Protecting Palatal Soft Tissue Donor Sites Using an Oral Mucoadhesive Bandage

Published on: February 17, 2026

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
20:33

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

Published on: July 4, 2019

Area of Science:

  • Orthopedic Surgery
  • Plastic Surgery
  • Trauma Surgery

Background:

  • Warfare-induced open fractures with extensive soft tissue loss present complex reconstructive challenges.
  • Effective soft tissue coverage is crucial for limb salvage in combat casualties.

Purpose of the Study:

  • To review current and evolving treatment strategies for soft tissue coverage of warfare-induced extremity wounds.
  • To evaluate the success rates of flap reconstruction in combat-injured personnel.

Main Methods:

  • A review of literature and data from 2004-2009 on extremity flap reconstructions in combat-injured personnel.
  • Analysis of injury patterns, reconstruction methods (pedicled vs. free flaps), flap types, and outcomes.

Main Results:

  • Seventy-five extremity reconstructions were performed using various flap types in the subacute period (7 days to 3 months).
  • Flap success rate was 97%, with a limb salvage rate of 94%.
  • Early postoperative infections occurred in 13% of patients; total flap loss was 2.8%.

Conclusions:

  • Modern military limb reconstruction strategies yield low flap loss and high limb salvage rates in carefully selected patients.
  • This protocol is potentially applicable to high-energy civilian trauma with contaminated wounds.