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Updated: Jun 14, 2026
Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
Published on: February 14, 2022
Pediatric lung transplantation
M Solomon1, H Grasemann, S Keshavjee
1Department of Pediatrics, Division of Respiratory Medicine and Transplant Centre, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada. melinda.solomon@sickkids.ca
Insights
Pediatric lung transplantation offers a vital therapy for children with end-stage lung disease. Successful outcomes require multidisciplinary collaboration and managing challenges like organ scarcity and immunosuppression.
Area of Science:
- Pediatric Pulmonology
- Thoracic Surgery
- Transplant Medicine
Background:
- Lung transplantation is a critical treatment for pediatric patients with severe end-stage lung disease.
- Effective management necessitates close collaboration among primary care physicians, transplant teams, patients, and families.
Observation:
- Key challenges include donor organ availability, immunosuppressive drug toxicity, and preventing obliterative bronchiolitis.
- Optimizing recipient growth, development, and quality of life is paramount.
Findings:
- This article reviews the current landscape of pediatric lung transplantation.
- It details indications for listing, recipient and donor evaluation, surgical procedures, and graft dysfunction.
Implications:
- Understanding risk factors and outcomes is crucial for improving pediatric lung transplant success.
- Future directions aim to enhance long-term graft survival and recipient well-being.
Abstract:
Lung transplantation is an accepted therapy for selected pediatric patients with severe end-stage vascular or parenchymal lung disease. Collaboration between the patients' primary care physicians, the lung transplant team, patients, and patients' families is essential. The challenges of this treatment include the limited availability of suitable donor organs, the toxicity of immunosuppressive medications needed to prevent rejection, the prevention and treatment of obliterative bronchiolitis, and maximizing growth, development, and quality of life of the recipients. This article describes the current status of pediatric lung transplantation, indications for listing, evaluation of recipient and donor, updates on the operative procedure,graft dysfunction, and the risk factors, outcomes, and future directions.
