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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

Prevention and treatment of infectious complications after solid organ transplantation in children

Upton Allen1, Michael Green

  • 1Department of Paediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada. upton.allen@sickkids.ca

Pediatric Clinics of North America
|April 8, 2010
PubMed

Insights

Infectious diseases pose significant risks for pediatric transplant recipients, impacting outcomes. This review covers major infections, prevention, and treatment strategies in children post-transplant.

Area of Science:

  • Pediatric Medicine
  • Transplant Surgery
  • Infectious Diseases

Background:

  • Infectious diseases are a primary concern following organ transplantation, affecting patient outcomes.
  • Pediatric transplant recipients face unique infection risks due to developing immunity and immunosuppressive therapy.
  • Infections can lead to direct clinical syndromes and indirect immune-mediated effects.

Purpose of the Study:

  • To review major infections in pediatric organ transplant recipients.
  • To highlight current prevention and treatment strategies for post-transplant infections in children.
  • To provide consensus-based recommendations for managing infections in this vulnerable population.

Main Methods:

  • Literature review of major infections after pediatric organ transplantation.
  • Analysis of current prevention strategies.
  • Summary of treatment approaches based on available data and expert consensus.

Main Results:

  • Children are susceptible to various infections post-transplantation, influenced by immune status and immunosuppression.
  • Common infections include mononucleosis, pneumonia, gastroenteritis, and hepatitis.
  • Both direct and indirect consequences of infections impact patient health and graft survival.

Conclusions:

  • Effective management of infections is crucial for successful pediatric organ transplantation.
  • Proactive prevention, accurate diagnosis, and timely treatment are essential.
  • This review provides a framework for addressing infectious complications in pediatric transplant patients.

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