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Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Related Experiment Video

Updated: Jun 14, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Posttransplant lymphoproliferative diseases.

Thomas G Gross1, Barbara Savoldo, Angela Punnett

  • 1Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, OSU School of Medicine, Columbus, OH 43205, USA.

Pediatric Clinics of North America
|April 8, 2010
PubMed
Summary
This summary is machine-generated.

Children undergoing solid organ transplantation (SOT) face a significantly higher cancer risk. Posttransplant lymphoproliferative disease (PTLD), often linked to Epstein-Barr virus, is the most common malignancy in these young patients.

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Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
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Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line

Published on: May 10, 2017

Related Experiment Videos

Last Updated: Jun 14, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

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Published on: May 2, 2013

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
12:58

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line

Published on: May 10, 2017

Area of Science:

  • Oncology
  • Immunology
  • Pediatrics

Background:

  • Solid organ transplantation (SOT) recipients have a 5-10 fold increased cancer risk compared to the general population.
  • Cancer risk after SOT exceeds 50% by 20 years post-transplant and escalates with age.
  • Children are particularly vulnerable to post-transplant malignancies.

Purpose of the Study:

  • To review the pathology, immunobiology, epidemiology, and clinical features of posttransplant lymphoproliferative disease (PTLD) in pediatric SOT recipients.
  • To highlight PTLD as the predominant cancer in this population.
  • To emphasize the need for continued research into PTLD's complex biology and treatment.

Main Methods:

  • Literature review of pathology, immunobiology, epidemiology, and clinical data on PTLD in pediatric SOT.
  • Analysis of cancer incidence and risk factors in SOT patients, with a focus on pediatric cases.
  • Synthesis of current understanding of PTLD, particularly Epstein-Barr virus association.

Main Results:

  • Posttransplant lymphoproliferative disease (PTLD) is the most frequent malignancy in children after SOT, comprising 50% of all cancers.
  • PTLD presents as a diverse group of disorders with varied pathological and clinical presentations.
  • Epstein-Barr virus infection is associated with the majority of PTLD cases in children.

Conclusions:

  • PTLD is a significant cause of long-term morbidity and mortality in pediatric SOT recipients.
  • Understanding the complex biological and therapeutic aspects of PTLD requires ongoing systematic investigation.
  • Further research is crucial for improving outcomes for children with PTLD post-transplant.