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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

A quantitative trait locus on chr.4 regulates thymic involution.

Ritu Kumar¹, Serine Avagyan, Hans-Willem Snoeck

¹Department of Gene and Cell Medicine, Mount Sinai of School of Medicine, Gustave L. Levy Place, PO Box 1496, New York, NY 10029, USA.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

|April 8, 2010

Summary

This summary is machine-generated.

Scientists identified a gene region on mouse chromosome 4 that significantly impacts thymic involution, the aging of the thymus. This discovery offers new insights into the genetic regulation of this crucial immune aging process.

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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

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Published on: September 26, 2013

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

Area of Science:

Immunology
Genetics
Aging Research

Background:

Age-associated thymic involution, a decline in thymus function with age, lacks understood mechanisms.
Genetic variation between mouse strains influences thymic involution.
Identifying genes involved could illuminate the process of immune aging.

Purpose of the Study:

To investigate the hypothesis that a quantitative trait locus (QTL) on mouse chromosome 4 regulates thymic involution.
To identify genetic factors contributing to age-related thymus shrinkage.

Main Methods:

Utilized B6.D2-chr.4 congenic mice, which possess a specific region of chromosome 4 introgressed from DBA/2 mice into a C57BL/6 background.
Compared thymus size and the maintenance of early thymic precursors in aged congenic mice versus aged C57BL/6 control mice.

Main Results:

Aged B6.D2-chr.4 congenic mice exhibited larger thymi compared to aged C57BL/6 controls.
Congenic mice showed better preservation of early thymic precursors.
These findings pinpoint a QTL on the telomeric region of chromosome 4, designated Ti1 (thymic involution 1), as a regulator of thymic involution.

Conclusions:

The telomeric region of mouse chromosome 4 contains a significant QTL (Ti1) that regulates thymic involution.
The identified QTL (Ti1) may be identical to Tb2r1, a previously identified QTL regulating hematopoietic stem and progenitor cell responsiveness to TGF-beta 2.
This research provides a key genetic locus for understanding and potentially intervening in thymus aging.